Meeting Report: Alternatives for Developmental Neurotoxicity Testing
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منابع مشابه
Meeting Report: Alternatives for Developmental Neurotoxicity Testing
Developmental neurotoxicity testing (DNT) is perceived by many stakeholders to be an area in critical need of alternatives to current animal testing protocols and guidelines. To address this need, the Johns Hopkins Center for Alternatives to Animal Testing (CAAT), the U.S. Environmental Protection Agency, and the National Toxicology Program are collaborating in a program called TestSmart DNT, t...
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analogous threshold rules applied, followed by expert intervention for data points for which the automated system failed to generate an expert call. The semi-automated expert calls, which were completed in 5 days, compared to 3 weeks for the manual approach, agreed with the human expert calls for 93% of the 6956 chemicals based on a conservative approach for all combined classified calls. As a ...
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There is a great concern about children’s health as the developing brain in foetuses and children is much more vulnerable to injury caused by different classes of chemicals than the adult brain. This vulnerability is partly due to the fact that the adult brain is well protected against chemicals by the blood brain barrier (BBB) and children have increased absorption rates and diminished ability...
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A large number of chemicals may exert adverse effects on the central and/or peripheral nervous system. A commonly recommended strategy for neurotoxicity testing is that of a tiered approach aimed at identifying and characterizing the neurotoxicity of a compound. Guidelines exist in the United States and other countries that define the tests to be utilized in tier 1 testing. To address problems ...
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BACKGROUND To establish zebrafish as a developmental toxicity model, we used 7 well-characterized compounds to examine several parameters of neurotoxicity during development. METHODS Embryos were exposed by semistatic immersion from 6 hrs postfertilization (hpf). Teratogenicity was assessed using a modified method previously developed by Phylonix. Dying cells in the brain were assessed by acr...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 2007
ISSN: 0091-6765,1552-9924
DOI: 10.1289/ehp.9841